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Hormone Levels to Check Before Embryo Transfer for Successful Implantation

Before an embryo transfer, several hormone levels should be checked to ensure the best chances of implantation and a successful pregnancy. The key hormones to assess include:

1. Estradiol (E2) - Estrogen

  • Role: Ensures the endometrium is thick and receptive.
  • Recommended range:
    • Fresh cycle (after egg retrieval, before transfer): 2000–4000 pg/mL
    • Frozen embryo transfer (FET) cycle (before progesterone starts): 200–350 pg/mL
  • Low E2 (<150 pg/mL) may indicate poor endometrial development.
  • Very high E2 (>5000 pg/mL) may indicate ovarian hyperstimulation syndrome (OHSS), which can reduce implantation success.

2. Progesterone (P4) - Luteal Support

  • Role: Ensures the endometrium is mature and ready for implantation.
  • Recommended range:
    • Before embryo transfer in FET cycles: <1.5 ng/mL before starting progesterone supplementation.
    • During the luteal phase (post-transfer, on supplementation):
      • Fresh cycle: >10 ng/mL (ideally 15–20 ng/mL).
      • Frozen cycle (on progesterone support): >10–20 ng/mL.
  • Low progesterone (<10 ng/mL post-transfer) may increase miscarriage risk.

3. Prolactin (PRL)

  • Role: High prolactin levels can interfere with progesterone secretion, affecting implantation.
  • Recommended range: 5–25 ng/mL
  • High prolactin (>25 ng/mL) may require treatment with medications like Cabergoline or Bromocriptine before transfer.

4. Luteinizing Hormone (LH) [For Natural Cycles]

  • Role: Tracks ovulation in a natural FET cycle.
  • Recommended range: LH surge confirms ovulation before embryo transfer.

5. Thyroid-Stimulating Hormone (TSH)

  • Role: Essential for early pregnancy maintenance.
  • Recommended range: <2.5 mIU/L (high TSH can increase miscarriage risk).

6. Anti-Müllerian Hormone (AMH) [For Fresh Cycles]

  • Role: Assesses ovarian reserve but is not needed for FET.

7. Human Chorionic Gonadotropin (hCG) [For Triggered Cycles]

  • Role: Ensures the trigger shot was effective in fresh cycles.

These ranges apply to all patients undergoing embryo transfer, whether in a fresh or frozen cycle.


Disclaimer

The information provided in this blog is for educational and informational purposes only and is not intended as medical advice. While every effort has been made to ensure accuracy, the content is based on general research, nutritional principles, and personal insights.

Individual health conditions, fertility treatments, and dietary needs vary from person to person. Always consult with your fertility specialist, doctor, or a registered dietitian before making any changes to your diet, supplements, or treatment plan, especially during fertility treatments like IVF, IUI, or embryo transfer.

This blog does not claim to diagnose, treat, cure, or prevent any medical conditions. The author and publisher are not responsible for any adverse effects resulting from the use of the information provided.

If you have any specific medical concerns, please seek professional medical advice from a qualified healthcare provider.

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